The 3DGD: a database of genome 3D structure

نویسندگان

  • Chao Li
  • Xiao Dong
  • Haiwei Fan
  • Chuan Wang
  • Guohui Ding
  • Yixue Li
چکیده

UNLABELLED The studies of chromatin 3D structure help us to understand its formation and function. Techniques combining chromosome conformation capture and next generation sequencing can capture chromatin structure information and has been applied to several different species and cell lines. We built 3DGD (3D Genome Database), a database that currently collected Hi-C data on four species, for easy accessing and visualization of chromatin 3D structure data. With the integration of other omics data such as genome-wide protein-DNA-binding data, this data source would be useful for researchers interested in chromatin structure and its biological functions. AVAILABILITY AND IMPLEMENTATION The 3DGD v1.1, data browser, downloadable files and documentation are available at: http://3dgd.biosino.org/.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Prediction of 3D protein Structure based on Mutation of AKAP3 and PLOD3 Gene in Case of Non-Obstructive Azoospermia

Background: The present study has been designed with the aim of evaluating A-kinase anchoring proteins 3 (AKAP3)and Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3) gene mutations and prediction of 3D proteinstructure for ligand binding activity in the cases of non-obstructive azoospermic male.Materials and Methods: Clinically diagnosed cases of non-obstructive azoos...

متن کامل

In Silico Prediction and Docking of Tertiary Structure of Multifunctional Protein X of Hepatitis B Virus

Hepatitis B virus (HBV) infection is a universal health problem and may result into acute, fulminant, chronic hepatitis liver cirrhosis, or hepatocellular carcinoma. Sequence for protein X of HBV was retrieved from Uniprot database. ProtParam from ExPAsy server was used to investigate the physicochemical properties of the protein. Homology modeling was carried out using Phyre2 server, and refin...

متن کامل

Comparative bioinformatics analysis of a wild diploid Gossypium with two cultivated allotetraploid species

Background: Gossypium thurberi is a wild diploid species that has been used to improve cultivated allotetraploid cotton. G. thurberi belongs to D genome, which is an important wild bio-source for the cotton breeding and genetic research. To a certain degree, chloroplast DNA sequence information are a versatile tool for species identification and phylogenetic implications in plants. Different ch...

متن کامل

3DIV: A 3D-genome Interaction Viewer and database

Three-dimensional (3D) chromatin structure is an emerging paradigm for understanding gene regulation mechanisms. Hi-C (high-throughput chromatin conformation capture), a method to detect long-range chromatin interactions, allows extensive genome-wide investigation of 3D chromatin structure. However, broad application of Hi-C data have been hindered by the level of complexity in processing Hi-C ...

متن کامل

Developing a BIM-based Spatial Ontology for Semantic Querying of 3D Property Information

With the growing dominance of complex and multi-level urban structures, current cadastral systems, which are often developed based on 2D representations, are not capable of providing unambiguous spatial information about urban properties. Therefore, the concept of 3D cadastre is proposed to support 3D digital representation of land and properties and facilitate the communication of legal owners...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Bioinformatics

دوره 30 11  شماره 

صفحات  -

تاریخ انتشار 2014